In the wild, Ceropegia sandersonii is found in South Africa and Swaziland and the coastal regions of Mozambique where it inhabits tropical and subtropical regions. This Ceropegia has thick, fleshy leaves but it is the plant's underground storage organs that ensure its survival in periods of drought. In the wet season Ceropegia sandersonii develops mottled green and white flowers with a hint of lime fragrance that attracts flies looking for a place to lay their eggs. When a fly crawls into the flower, an oily substance ensures it slides down the corolla tube and becomes trapped. Small hairs pointing downwards prevent it from escaping. The flowers contain nectar and cells permeable to sunlight, fooling the fly into think there is an exit towards the light. When the fly starts to consume the plant's nectar it becomes covered in pollen. After a couple of days the flower changes position and the small hairs point in the opposite direction allowing the fly to escape. It can then start pollinating other flowers.

Ceropegia sandersonii is fairly straightforward to care for. With sufficient amounts of water and light it will grow and bloom all year round. Ceropegia sandersonii can tolerate dry air and thrives at room temperature. It can handle fluctuations in temperature but never lower than 12 degrees Celsius. The flowers normally develop on young shoots. It is therefore advisable to prune Ceropegia sandersonii in order to produce the maximum number of blooms. New shoots can be left to trail in a hanging basket or trained on a stake or trellis. Flowers take about three weeks to develop. Keep the soil moist and place the plant in bright light but not in direct sunlight. Do not water excessively and feed sparingly. Ceropegia sandersonii is not unduly susceptible to pests or diseases.